Bioactive Small Molecules
Cayman Chemical Cyfluthrin, Purity: ≥98%, CAS: 68359-37-5, 100 mg
A pyrethroid insecticide; modulates Nav channels; slowly activates recombinant rat Nav1.8 expressed in Xenopus oocytes and delays inactivation; decreases the mean burst rate in rat primary neurons (IC50 = 0.99 μM, respectively); toxic to various insects, including A. melinus, G. ashmeadi, E. eremicus, and E. formosa (LC50s = 7, 67, 96, and 63 ng/ml, respectively) and the A. sinensis mosquito (LC50 = 0.446 ppm); toxic to A. mellifera honeybees (LD50 = 0.22 ppm), affecting locomotor activity and wing fanning behavior at 10 ng/bee
Medchemexpress LLC Phospho-Histone H2A.X (Ser139) Antibody (YA844) | 50 UL
Phospho-Histone H2A.X (Ser139) Antibody (YA844) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody. This antibody targets Phospho-Histone H2A.X (Ser139) and shows reactivity with Human and Mouse samples. It is suitable for use in Western Blot (WB) and Immunocytochemistry/Immunofluorescence (ICC/IF) applications, with an observed band size of 15 kDa. Other aliases for the target include H2A.X, H2AFX, H2a/x, HIST5-2AX, and Histone H2A.X, gamma H2A.X. The antibody is affinity purified.
- Mouse-derived and non-conjugated IgG1 monoclonal antibody
- Targets Phospho-Histone H2A.X (Ser139)
- Reactive with human and mouse samples
- Suitable for Western Blot (WB) and Immunocytochemistry/Immunofluorescence (ICC/IF)
- Observed band size of 15 kDa
- Affinity purified for enhanced specificity
eMolecules 1539318-36-9 | Medchem Express | DFHBI-1T | 5mg | 628192275 | HY-110251 | MFCD29081187 | 320.219 | C13H9F5N2O2
Medchem Express | 3-Methyluridine | 5mg | 448039072 | HY-113138 | 2140-69-4 | 258.230 | C10H14N2O6
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Edaravone impurity 2 | 60484-29-9 | MFCD00448479 | 5g
Edaravone impurity 2 is an impurity of Edaravone (HY-B0099)
Medchemexpress LLC Mc-Gly-Gly-Phe-Gly-(R)-cyclopropane-exatecan | 2414254-51-4 | 97.4% | 1074.12 | 5 MG
Mc-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan (SHR-A1811 Drug-linker) is an agent-linker conjugate for Antibody-Drug Conjugates (ADC), consisting of Exatecan. Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM).
- Contains Exatecan, a DNA Topoisomerase I inhibitor.
- Solid, white to light yellow appearance.
- Soluble in DMSO (100 mg/mL).
- In vivo solubility in 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline (≥ 2.5 mg/mL) or 10% DMSO, 90% Corn Oil (≥ 2.5 mg/mL).
- Store at -20°C, sealed, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month.
- For research use only.
Cayman Chemical Insulin Sensitizer C59, Purity: ≥98%, CAS: 2761446-81-3, 5 mg
A potentiator of insulin-induced Glut4 plasma membrane translocation; enhances insulin-stimulated increases in plasma membrane levels of Glut4 in a reporter assay using C2C12 cells at 10 µM; decreases fasting blood levels of glucose, fasting plasma levels of insulin, and body weight in mice fed a high-fat diet at 10 mg/kg per day; potentiates insulin-induced increases in the plasma membrane translocation of Glut4 in the forelimbs, hind limbs, brown adipose tissues, and heart but not brain or liver in mice in a model of diet-induced obesity
Medchemexpress LLC PPARγ agonist 5 | 915124-86-6 | 98.59% | 513.63 | 25 MG
PPARγ agonist 5 is a potent and selective agonist of PPARγ with potential for research into cancer diseases. It appears as a solid with a white to off-white color.
- Potent and selective agonist of PPARγ
- Potential for cancer disease research
- Solid, white to off-white appearance
- Purity: 98.59%
- Molecular weight: 513.63
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC Mtb ATP synthase-IN-1 | 2642394-38-3 | 98.6% | 323.30 | 50 MG
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with a MIC of 0.452-0.499 μg/mL against Mtb. It demonstrates good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. This compound is suitable for researching anti-mycobacterium applications.
- Potent Mtb ATP synthase inhibitor
- MIC of 0.452-0.499 μg/mL against Mtb
- Good metabolic stability
- Low cytotoxicity (Vero IC50 > 64 μg/mL)
- Acceptable oral bioavailability
- Suitable for anti-mycobacterium research
Medchemexpress LLC Ac-vrpr-amc tfa | 919515-51-8 | 99.6% | 953.88 | 5 MG
Ac-VRPR-AMC TFA is a fluorogenic metacaspase substrate. It can be used to assay metacaspase activity. This product is for research use only.
- Fluorogenic metacaspase substrate
- Suitable for assaying metacaspase activity
- Research use only
- Molecular weight: 953.88
- Purity: 99.6%
- White to off-white solid appearance
- Soluble in water at 100 mg/mL or more
Medchemexpress LLC Brepocitinib (P-Tosylate) | 2140301-96-6 | 99.99% | 561.60 | 100 MG
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor. It inhibits JAK1 and TYK2 with IC50s of 17 nM and 23 nM, respectively, and also inhibits JAK2 and JAK3. This compound is intended for research use only.
- Potent dual JAK1 and TYK2 inhibitor
- Inhibits JAK1 with an IC50 of 17 nM
- Inhibits TYK2 with an IC50 of 23 nM
- Inhibits JAK2 and JAK3
- Applicable for in vitro and in vivo research
Cayman Chemical Velneperit, Purity: ≥98%, CAS: 342577-38-2, 10 mg
An antagonist of NPY receptor Y5 (Ki = 5.3 nM); selective for Y5 over Y1, Y2, and Y4 receptors, as well as a panel of 44 receptors, ion channels, transporters and enzymes, at 10 µM; inhibits NPY-induced decreases in forskolin-induced cAMP production in CHO-K1 cells expressing human Y5 (IC50 = 169 nM); suppresses Y5 agonist-induced increases in food intake in DIO mice at 50 mg/kg; reduces body weight gain and suppresses food intake in DIO mice
Cayman Chemical GLPG2938, Purity: ≥98%, CAS: 2130996-00-6, 25 mg
An S1P2 antagonist; inhibits S1P-induced calcium flux in CHO cells overexpressing human S1P2 (IC50 = 8.8 nM); inhibits S1P-induced IL-8 release in HFL1 cells (IC50 = 0.6 nM) and S1P-induced contraction of human lung fibroblasts; prevents epithelial damage and pulmonary fibrosis, structural distortion, and inflammation in a mouse model of bleomycin-induced pulmonary fibrosis at 3, 10, and 30 mg/kg
Cayman Chemical Loxoribine, Purity: ≥98%, CAS: 121288-39-9, 50 mg
A guanosine derivative and an agonist of TLR7; selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM; induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC50s = 10-50, 3-20, and 13-22 μM, respectively); increases production of IL-12, IL-23, IL-27, and IL-10 by human MoDCs at 250 μM; loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4+ T cells compared to control MoDCs; reduces the number of pulmonary metastases in the B16 mouse model of melanoma at 120 mg/kg, an effect enhanced by co-administration of IL-2; exhibits adjuvant activity in mice immunized with a B16 tumor vaccine
Medchemexpress LLC Zinc05007751 | 591239-68-8 | 99.3% | 304.30 | 5 MG
ZINC05007751 is a potent and selective NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. It exhibits antiproliferative activity across a range of human cancer cell lines, such as MDA-MB-231, PEO1, NCI-H1299, and HCT-15. It shows synergistic effects when combined with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line (PEO1) and is highly selective, showing no significant activity against NEK2, NEK7, and NEK9.
- Potent and selective NEK6 inhibitor
- Exhibits antiproliferative activity against human cancer cell lines
- Shows synergistic effects with Cisplatin and Paclitaxel in BRCA2 mutated ovarian cancer cells
- Induces perturbation of PEO1 cell cycle
- Highly selective against NEK2, NEK7, and NEK9
- Provided as a brown to black solid
Medchemexpress LLC MAO-B-IN-9 | 2416910-88-6 | 99.7% | 300.40 | 25 MG
MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible, and time-dependent MAO-B (monoamine oxidase B) inhibitor with an IC50 of 0.18 μM. It prevents Aβ1-42-induced neuronal cell death and exhibits neuroprotective effects, potentially due to its Aβ1-42 anti-aggregation properties. MAO-B-IN-9 is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Potent, selective, BBB-penetrated, irreversible, and time-dependent MAO-B inhibitor
- Prevents Aβ1-42-induced neuronal cell death
- Exhibits neuroprotective effects
- Click chemistry reagent with alkyne group for CuAAc reactions